Interne Geneeskunde

De vakgroep beoefend de Interne Geneeskunde in al haar diagnostische en klinische mogelijkheden.

De vakgroep bestaat uit de volgende sub-specialismen: Oncologie, Hematologie, Nefrologie, Vasculaire geneeskunde, Algemeen Interne, Endocrinologen en Intensive Care.
Er lopen diverse onderzoekslijnen met origineel wetenschappelijk onderzoek. De vakgroep Interne Geneeskunde verzorgt het perifere deel van de opleiding tot internist (4 jaar) met daarin onder andere de stages oncologie, hematologie en nefrologie. Iedere interne sectie levert top klinische zorg waarbij de patiënt centraal staat. De sfeer in de maatschap is zonder meer open en stimulerend.

 

Leden

dr. E.F.H. (Eric) van Bommel

dr. E.F.H. (Eric) van Bommel

Nefrologie, vasculaire geneeskunde

J. (Joan) van den Bosch

J. (Joan) van den Bosch

Oncologie

dr. S.C.C. (Simone) Hartong

dr. S.C.C. (Simone) Hartong

Vasculaire geneeskunde

dr. R.M. (Rosalie) Kiewiet-Kemper

dr. R.M. (Rosalie) Kiewiet-Kemper

Endocrinologie, obesitas

J.J.E.M. (Jos) Kitzen

J.J.E.M. (Jos) Kitzen

Oncologie

M.R. (Mario) Korte

M.R. (Mario) Korte

Nefrologie, medisch manager vakgroep

R.J.M. (Ruud) van Leendert

R.J.M. (Ruud) van Leendert

Algemene interne geneeskunde

dr. M.D. (Mark-David) Levin

dr. M.D. (Mark-David) Levin

Hematologie

J.A.A. (Ton) Meijer

J.A.A. (Ton) Meijer

Endocrinologie

dr. M.W.C.J. (Mariëtte) Schoofs

dr. M.W.C.J. (Mariëtte) Schoofs

Endocrinologie

dr. P.J.H. (Peter) Smak Gregoor

dr. P.J.H. (Peter) Smak Gregoor

Nefrologie, vasculaire geneeskunde

M. (Marija) Trajkovic

M. (Marija) Trajkovic

Oncologie

E.J.H.M. (Ernst-Jan) van der Weijgert

E.J.H.M. (Ernst-Jan) van der Weijgert

Algemene interne geneeskunde

dr. P.E. (Peter) Westerweel

dr. P.E. (Peter) Westerweel

Hematologie, duikgeneeskunde

dr. E.T. (Elske ) Massolt

dr. E.T. (Elske ) Massolt

Endocrinologie

E. (Eva ) de Jongh

E. (Eva ) de Jongh

Hematologie

dr. J.B. (Jeroen) van der Net

dr. J.B. (Jeroen) van der Net

Nefrologie

E.W. (Esther) Bouman

E.W. (Esther) Bouman

Internist-oncoloog

Publicaties

01aug

A new diagnostic work-up for defining anemia etiologies: a cohort study in patients ≥ 50 years in general practices.

Auteurs: Schop A, Stouten K, Riedl JA, van Houten RJ, Leening MJG, van Rosmalen J, Bindels PJE, Levin MD.

01aug

Proteomic markers with prognostic impact on outcome of chronic lymphocytic leukemia patients under chemo-immunotherapy; results from the HOVON 109 study.

Auteurs: Saberi Hosnijeh F, van der Straten L, Kater AP, van Oers MHJ, Posthuma WFM, Chamuleau MED, Bellido M, Doorduijn JK, van Gelder M, Hoogendoorn M, de Boer F, Te Raa GD, Kerst JM, Marijt EWA, Raymakers RAP, Koene HR, Schaafsma MR, Dobber JA, Tonino SH, Kersting SS, Langerak AW, Levin MD.

01aug

Survival and Quality of Life after Early Discharge in Low-Risk Pulmonary Embolism.

Auteurs: Barco S, Schmidtmann I, Ageno W, Anušić T, Bauersachs RM, Becattini C, Bernardi E, Beyer-Westendorf J, Bonacchini L, Brachmann J, Christ M, Czihal M, Duerschmied D, Empen K, Espinola-Klein C, Ficker JH, Fonseca C, Genth-Zotz S, Jiménez D, Harjola VP, Held M, Iogna Prat L, Lange TJ, Lankeit M, Manolis A, Meyer A, Münzel T, Mustonen P, Rauch-Kroehnert U, Ruiz-Artacho P, Schellong S, Schwaiblmair M, Stahrenberg R, Valerio L, Westerweel PE, Wild PS, Konstantinides SV; HoT-PE Investigators.

01aug

Spectrum of histiocytic neoplasms associated with diverse haematological malignancies bearing the same oncogenic mutation.

Auteurs: Kemps PG, Hebeda KM, Pals ST, Verdijk RM, Lam KH, Bruggink AH, de Lil HS, Ruiterkamp B, de Heer K, van Laar JA, Valk PJ, Mutsaers P, Levin MD, Hogendoorn PC, van Halteren AG.

01aug

Changes in primary and secondary hemostasis in patients with CLL treated with venetoclax and ibrutinib.

Auteurs: Svanberg R, Ostrowski SR, Nasserinejad K, Kersting S, Dobber JA, Mattson M, Tran HTT, Levin MD, Mous R, Kater AP, Niemann CU.

01aug

Daratumumab, bortezomib, and dexamethasone in relapsed or refractory multiple myeloma: subgroup analysis of CASTOR based on cytogenetic risk.

Auteurs: Weisel K, Spencer A, Lentzsch S, Avet-Loiseau H, Mark TM, Spicka I, Masszi T, Lauri B, Levin MD, Bosi A, Hungria V, Cavo M, Lee JJ, Nooka A, Quach H, Munder M, Lee C, Barreto W, Corradini P, Min CK, Chanan-Khan AA, Horvath N, Capra M, Beksac M, Ovilla R, Jo JC, Shin HJ, Sonneveld P, Casneuf T, DeAngelis N, Amin H, Ukropec J, Kobos R, Mateos MV.

01aug

Postoperative parathyroid hormone levels as a predictor for persistent hypoparathyroidism.

Auteurs: Lončar I, Dulfer RR, Massolt ET, Timman R, de Rijke YB, Franssen GJH, Burger PJWA, Smit C, van der Horst FAL, Peeters RP, van Eijck CHJ, van Ginhoven TM.

01jul

Preventing overuse of laboratory diagnostics: a case study into diagnosing anaemia in Dutch general practice.

Auteurs: Kip MMA, Oonk MLJ, Levin MD, Schop A, Bindels PJE, Kusters R, Koffijberg H.

01jul

Intimal angiosarcoma masquerading as retroperitoneal fibrosis.

Auteurs: van Baalen EA, Hendriksz TR, Brans B, Westenend PJ, van Bommel EFH.

01jul

Prevalence of COVID-19 diagnosis in Dutch CML patients during the 2020 SARS-CoV2 pandemic. A prospective cohort study.

Auteurs: Ector GICG, Huijskens EGW, Blijlevens NMA, Westerweel PE.

01jul

Blood cell counts and lymphocyte subsets of patients admitted during the COVID-19 pandemic: a prospective cohort study.

Auteurs: Hengeveld PJ, Khader AO, de Bruin LHA, Geelen IGP, van Baalen EA, Jansen E, Bouwer NI, Balak Ö, Riedl JA, Langerak AW, Westerweel PE, Levin MD.

01jul

Rituximab-CHOP With Early Rituximab Intensification for Diffuse Large B-Cell Lymphoma: A Randomized Phase III Trial of the HOVON and the Nordic Lymphoma Group (HOVON-84)

Auteurs: Pieternella Johanna Lugtenburg, Peter de Nully Brown, Bronno van der Holt, Francesco A D’Amore, Harry R Koene, Eva de Jongh, Rob Fijnheer, Joost W van Esser, Lara H Böhmer, Johannes F Pruijt, Gregor E Verhoef, Mels Hoogendoorn, Memis Y Bilgin, Marcel Nijland, Nicole C van der Burg-de Graauw, Margreet Oosterveld, Kon-Siong G Jie, Thomas Stauffer Larsen, Marjolein W van der Poel, Maria B Leijs, Matthijs H Silbermann, Marinus van Marwijk Kooy, Aart Beker, Marie J Kersten, Jeanette K Doorduijn, Lidwine W Tick, Rolf E Brouwer, King H Lam, Coreline N Burggraaff, Bart de Keizer, Anne I Arens, Daphne de Jong, Otto S Hoekstra, Josée M Zijlstra-Baalbergen.

01jul

COVID-19 severity and mortality in patients with chronic lymphocytic leukemia: a joint study by ERIC, the European Research Initiative on CLL, and CLL Campus.

Auteurs: Scarfò L, Chatzikonstantinou T, Rigolin GM, Quaresmini G, Motta M, Vitale C, Garcia-Marco JA, Hernández-Rivas JÁ, Mirás F, Baile M, Marquet J, Niemann CU, Reda G, Munir T, Gimeno E, Marchetti M, Quaglia FM, Varettoni M, Delgado J, Iyengar S, Janssens A, Marasca R, Ferrari A, Cuéllar-García C, Itchaki G, Špaček M, De Paoli L, Laurenti L, Levin MD, Lista E, Mauro FR, Šimkovič M, Van Der Spek E, Vandenberghe E, Trentin L, Wasik-Szczepanek E, Ruchlemer R, Bron D, De Paolis MR, Del Poeta G, Farina L, Foglietta M, Gentile M, Herishanu Y, Herold T, Jaksic O, Kater AP, Kersting S, Malerba L, Orsucci L, Popov VM, Sportoletti P, Yassin M, Pocali B, Barna G, Chiarenza A, Dos Santos G, Nikitin E, Andres M, Dimou M, Doubek M, Enrico A, Hakobyan Y, Kalashnikova O, Ortiz Pareja M, Papaioannou M, Rossi D, Shah N, Shrestha A, Stanca O, Stavroyianni N, Strugov V, Tam C, Zdrenghea M, Coscia M, Stamatopoulos K, Rossi G, Rambaldi A, Montserrat E, Foà R, Cuneo A, Ghia P.

01jul

Disseminated cryptococcal disease during treatment with idelalisib and corticosteroids for follicular lymphoma

Auteurs: Hengeveld PJ, de Jongh E, Westerweel PE, Levin MD.

01jul

European Guideline on IgG4-related digestive disease – UEG and SGF evidence-based recommendations.

Auteurs; Löhr JM, Beuers U, Vujasinovic M, Alvaro D, Frøkjær JB, Buttgereit F, Capurso G, Culver EL, de-Madaria E, Della-Torre E, Detlefsen S, Dominguez-Muñoz E, Czubkowski P, Ewald N, Frulloni L, Gubergrits N, Duman DG, Hackert T, Iglesias-Garcia J, Kartalis N, Laghi A, Lammert F, Lindgren F, Okhlobystin A, Oracz G, Parniczky A, Mucelli RMP, Rebours V, Rosendahl J, Schleinitz N, Schneider A, van Bommel EF, Verbeke CS, Vullierme MP, Witt H; UEG guideline working group.

01jun

Ixazomib Treatment of IgA Multiple Myeloma With Hyperviscosity Syndrome.

Auteurs: Boiten HJ, Buijze M, Zweegman S, Levin MD.

01jun

Primary therapy and relative survival among elderly patients with chronic myeloid leukemia: a population-based study in the Netherlands, 1989-2017.

Auteurs: Ector GICG, Visser O, Westerweel PE, Janssen JJWM, Blijlevens NMA, Dinmohamed AG.

01jun

Response and Adherence to Nilotinib in Daily Practice (RAND Study): An In-Depth Observational Study of Chronic Myeloid Leukemia Patients Treated With Nilotinib.

Auteurs: Christel C L M Boons, Lonneke Timmers, Jeroen J W M Janssen, Peter E Westerweel, Nicole M A Blijlevens, Willem M Smit, Imke H Bartelink, Janneke A Wilschut, Eleonora L Swart, N Harry Hendrikse, Jacqueline G Hugtenburg.

01mei

Survival Continues to Increase in Chronic Lymphocytic Leukaemia: A Population-Based Analysis Among 20 468 Patients Diagnosed in the Netherlands Between 1989 and 2016.

Auteurs: Van der Straten L , Levin MD, Visser O, Posthuma EFM, Doorduijn JK, Kater AP, Dinmohamed AG

01mei

Long term follow up of mTOR inhibition for Erdheim-Chester disease.

Auteurs: Francesco Pegoraro, Valerio Maniscalco, Francesco Peyronel, Pieter J Westenend, Tadek R Hendriksz, Rosa M Roperto, Alessandro A Palumbo, Elena Sieni, Paola Romagnani, Eric F H van Bommel, Augusto Vaglio.

01mei

The Development of a Web-Based, Patient-Centered Intervention for Patients With Chronic Myeloid Leukemia (CMyLife): Design Thinking Development Approach.

Auteurs: Geneviève Icg Ector, Peter E Westerweel, Rosella Pmg Hermens, Karin Ae Braspenning, Barend Cm Heeren, Oscar Mf Vinck, Jan Jm de Jong, Jeroen Jwm Janssen, Nicole Ma Blijlevens.

01mei

Development of a Patient Centered Outcome Set for Patients With Multiple Myeloma to be Used in Clinical Practice.

Auteurs: Simone Oerlemans, M Christine Bennink, Mark David Levin, Annemiek Broijl, Marjolein Van der Klift, Judith Van Deursen, Daphne Vogels, Lonneke V Van de Poll-Franse, Pieter Sonneveld, Jan A Hazelzet, Lidwine W Tick.

01apr

Cardiac monitoring in HER2-positive patients on trastuzumab treatment: A review and implications for clinical practice.

Auteurs: Bouwer NI, Jager A, Liesting C, Kofflard MJM, Brugts JJ, Kitzen JJEM, Boersma E, Levin MD.

01apr

Longitudinal Analysis of the Effect of Radioiodine Therapy on Ovarian Reserve in Females with Differentiated Thyroid Cancer.

Auteurs: van Velsen EFS, Visser WE, van den Berg SAA, Kam BLR, van Ginhoven TM, Massolt ET, Peeters RP.

01apr

Results of the prematurely terminated TEMPLE randomized controlled trial in patients with myelodysplastic syndrome: liberal versus restrictive red blood cell transfusion threshold.

Auteurs: Gerard Jansen AJ, van den Bosch J, Te Boekhorst PAW, Schipperus MR, Beckers EAM.

01apr

Autologous haematopoietic stem-cell transplantation versus bortezomib-melphalan-prednisone, with or without bortezomib-lenalidomide-dexamethasone consolidation therapy, and lenalidomide maintenance for newly diagnosed multiple myeloma (EMN02/HO95): a multicentre, randomised, open-label, phase 3 study.

Auteurs: Cavo M, Gay F, Beksac M, Pantani L, Petrucci MT, Dimopoulos MA, Dozza L, van der Holt B, Zweegman S, Oliva S, van der Velden VHJ, Zamagni E, Palumbo GA, Patriarca F, Montefusco V, Galli M, Maisnar V, Gamberi B, Hansson M, Belotti A, Pour L, Ypma P, Grasso M, Croockewit A, Ballanti S, Offidani M, Vincelli ID, Zambello R, Liberati AM, Andersen NF, Broijl A, Troia R, Pascarella A, Benevolo G, Levin MD, Bos G, Ludwig H, Aquino S, Morelli AM, Wu KL, Boersma R, Hajek R, Durian M, von dem Borne PA, Caravita di Toritto T, Driessen C, Specchia G, Waage A, Gimsing P, Mellqvist UH, van Marwijk Kooy M, Minnema M, Mandigers C, Cafro AM, Palmas A, Carvalho S, Spencer A, Boccadoro M, Sonneveld P.

01apr

Long term follow up of mTOR inhibition for Erdheim-Chester disease.

Auteurs: Pegoraro F, Maniscalco V, Peyronel F, Westenend PJ, Hendriksz TR, Roperto RM, Palumbo AA, Sieni E, Romagnani P, van Bommel EFH, Vaglio A.

01apr

Emergencies on direct oral anticoagulants: Management, outcomes, and laboratory effects of prothrombin complex concentrate.

Auteurs: Bavalia R, Abdoellakhan R, Brinkman HJM, Brekelmans MPA, Hamulyák EN, Zuurveld M, Hutten BA, Westerweel PE, Olie RH, Ten Cate H, Kruip M, Middeldorp S, Meijer K, Coppens M

01mrt

Prognostic impact of low muscle mass and low muscle density in patients with diffuse large B-cell lymphoma.

Auteurs: Rier HN, Kharagjitsing H, van Rosmalen J, van Vugt J, Westerweel PE, de Jongh E, Kock M, Levin MD.

01mrt

A rare case of Waldenström’s macroglobulinaemia-associated cryoglobulinaemia vasculitis.

Auteurs: Burgers MMJ, Meijer JAA, van de Weijgert EJHM, de Jongh E.

01mrt

Bortezomib maintenance after R-CHOP, cytarabine and autologous stem cell transplantation in newly diagnosed patients with mantle cell lymphoma, results of a randomised phase II HOVON trial.

Auteurs: Doorduijn JK, Zijlstra JM, Lugtenburg PJ, Kersten MJ, Böhmer LH, Minnema MC, MacKenzie MA, van Marwijk Kooij R, de Jongh E, Snijders TJF, de Weerdt O, van Gelder M, Hoogendoorn M, Leys RBL, Kibbelaar RE, de Jong D, Chitu DA, Van’t Veer MB, Kluin-Nelemans HC.

01mrt

An Exceptional Vulvar Tumor: Myeloid Sarcoma of the Labia Majora.

Auteurs: Ramlakhan KP, Groenendijk FH, Levin MD, Noorduyn LA, Kooi SG.

01mrt

Possible hampered effectiveness of second-line treatment with rituximab-containing chemotherapy without signs of rituximab resistance: a population-based study among patients with chronic lymphocytic leukemia.

Auteurs: van der Straten L, Kater AP, Doorduijn JK, van den Broek EC, Posthuma EFM, Dinmohamed AG, Levin MD.

01mrt

Diving with hypertension and antihypertensive drugs.

Auteurs: Westerweel PE, Rienks R, Sakr A, Taher A.

01feb

The effectiveness of ibrutinib in chronic lymphocytic leukaemia: a nationwide, population-based study in the Netherlands.

Auteurs: van der Straten L, Levin MD, Visser O, Blijlevens NMA, Cornelissen JJ, Doorduijn JK, Kater AP, Dinmohamed AG.

01feb

Validation of the FIRST Simplified Frailty Scale Using the ECOG Performance Status Instead of Patient-Reported Activities.

Auteurs: Stege CAM, van der Holt B, Dinmohamed AG, Sonneveld P, Levin MD, van de Donk NWCJ, Mellqvist UH, Waage A, Zweegman S.

01feb

Functional Differences Between EBV- and CMVSpecific CD8+ T cells Demonstrate Heterogeneity of T cell Dysfunction in CLL.

Auteurs: Hofland T, de Weerdt I, Endstra S, Jongejan A, Platenkamp L, Remmerswaal EBM, Moerland PD, Ten Berge IJM, Levin MD, Kater AP, Tonino SH.

01feb

Lenalidomide added to standard intensive treatment for older patients with AML and high-risk MDS.

Auteurs: Ossenkoppele GJ, Breems DA, Stuessi G, van Norden Y, Bargetzi M, Biemond BJ, A von dem Borne P, Chalandon Y, Cloos J, Deeren D, Fehr M, Gjertsen B, Graux C, Huls G, Janssen JJJW, Jaspers A, Jongen-Lavrencic M, de Jongh E, Klein SK, van der Klift M, van Marwijk Kooy M, Maertens J, Micheaux L, van der Poel MWM, van Rhenen A, Tick L, Valk P, Vekemans MC, van der Velden WJFM, de Weerdt O, Pabst T, Manz M, Löwenberg B; Dutch-Belgian Hemato-Oncology Cooperative Group (HOVON) and Swiss Group for Clinical Cancer Research (SAKK).

01feb

Ixazomib-Thalidomide-low dose dexamethasone induction followed by maintenance therapy with ixazomib or placebo in newly diagnosed multiple myeloma patients not eligible for autologous stem cell transplantation; results from the randomized phase II HOVON-126/NMSG 21.13 trial.

Auteurs: Zweegman S, Stege CAM, Haukas E, Schjesvold FH, Levin MD, Waage A, Leys RBL, Klein SK, Szatkowski D, Axelsson P, Hieu Do T, Knut-Bojanowska D, van der Spek E, Svirskaite A, Klostergaard A, Salomo M, Blimark C, Ypma PF, Mellqvist UH, Poddighe PJ, Stevens-Kroef M, van de Donk NWCJ, Sonneveld P, Hansson M, van der Holt B, Abildgaard N.

01jan

Early discharge and home treatment of patients with low-risk pulmonary embolism with the oral factor Xa inhibitor rivaroxaban: an international multicentre single-arm clinical trial.

Auteurs: Barco S, Schmidtmann I, Ageno W, Bauersachs RM, Becattini C, Bernardi E, Beyer-Westendorf J, Bonacchini L, Brachmann J, Christ M, Czihal M, Duerschmied D, Empen K, Espinola-Klein C, Ficker JH, Fonseca C, Genth-Zotz S, Jiménez D, Harjola VP, Held M, Iogna Prat L, Lange TJ, Manolis A, Meyer A, Mustonen P, Rauch-Kroehnert U, Ruiz-Artacho P, Schellong S, Schwaiblmair M, Stahrenberg R, Westerweel PE, Wild PS, Konstantinides SV, Lankeit M; HoT-PE Investigators.

01jan

Longitudinal Analysis of the Effect of Radioiodine Therapy on Ovarian Reserve in Females with Differentiated Thyroid Cancer.

Auteurs: van Velsen EFS, Visser WE, van den Berg S, Kam BLR, van Ginhoven TM, Massolt ET, Peeters RP.

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